Exon 2 containing myelin basic protein (MBP) transcripts are expressed in lesions of experimental allergic encephalomyelitis (EAE)
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چکیده
منابع مشابه
Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice
Experimental allergic encephalomyelitis (EAE) is an autoimmune demyelinating disease of the central nervous system (CNS) that occurs after immunization of animals with myelin basic protein (MBP). The disease is a prototype model for the study of antigen-specific T helper cell-mediated autoimmune disease. In SJL/J mice, EAE is mediated by T helper cells directed against a 40-amino acid COOH-term...
متن کاملThe pathophysiology of myelin basic protein-induced acute experimental allergic encephalomyelitis in the Lewis rat.
Histological and electrophysiological studies were performed on Lewis rats with acute experimental allergic encephalomyelitis (EAE) induced by inoculation with guinea-pig myelin basic protein (MBP) and Freund's adjuvant. The histological studies showed demyelination in the lumbar, sacral and coccygeal dorsal and ventral spinal roots and to a lesser extent in the spinal cord, including the dorsa...
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Antibodies with a specificity for myelin, as demonstrated by immunofluorescence, are present in the sera of rabbits injected with spinal cord. These antibodies react with both adult rabbit and human spinal cord but not with unmyelinated areas of neonatal human spinal cord.
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Scorbutic guinea pigs injected with CNS and mycobacterium to induce experimental allergic encephalomyelitis (EAE) showed no clear-cut neurological signs and failed to show histological evidence of central nervous system damage. The degree of protection afforded by vitamin C deprivation was related directly to the duration of the scorbutogenic diet and inversely to the strength of the CNS challe...
متن کاملEvaluate Toxocara Canis Excretory-Secretory Antigens in Experimental Allergic Encephalomyelitis (EAE)
BACKGROUND: Toxocara canis is the most prevalent intestinal roundworm of canid species. OBJECTIVES: This study aims to evaluate the effects of Toxocara canis excretory-secretory antigens (TcES Ag) on modulating the immune system in Experimental Allergic Encephalomyelitis (EAE) model. METHODS: Adult worms of T.canis were collected from dogs to obtain excretory-secretory antigens. Female C57BL/6m...
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ژورنال
عنوان ژورنال: Journal of Neuroimmunology
سال: 1997
ISSN: 0165-5728
DOI: 10.1016/s0165-5728(96)00137-3